Dongheon Lee, Ph.D.

Assistant Professor
Office
IRCB 3040F
Educational History
Postdoctoral associate, Department of Biomedical Engineering, Duke University
Ph.D. Chemical Engineering, Texas A&M University, 2020
B.S. Chemical & Biomolecular Engineering, Rice University, 2015
Research Interests
Synthetic biology
Systems biology
Antibiotic resistance
Process systems engineering
Hybrid modeling (machine learning + first principles)
Publications

D. Lee, M. T. Walls, K.-H. Siu, Y. Dai, K. Xu, C. P. Brangwynne, A. Chilkoti, J. L. Avalos, L. You, "Principles of metabolic pathway control by biomolecular condensates in cells," Nature Chemical Engineering, 2025, 2, 198–208.

Y. Dai, M. Farag, D. Lee, X. Zeng, K. Kim, H-I. Son, X. Guo, M. Ney, D.M. Shapiro, R.V. Pappu, A. Chilkoti, L. You, "Programmable synthetic biomolecular condensates for cellular control," Nature Chemical Biology, 2023, 19(4), 518-528.

D. Lee, A. Jayaraman, J. S. Kwon, "Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling," PLOS Computational Biology, 2020, 16(12), e1008472.

D. Lee, A. Jayaraman, J. S. Kwon, "Identification of Cell-to-Cell Heterogeneity through Systems Engineering Approaches," AIChE Journal, 2020, 66(5), e16925.

H.-K. Choi, D. Lee, A. Singla, H.-J. Wu, J.S. Kwon, "A theoretical approach to investigate lectin-glycan recognition principle on cell membrane surfaces," Glycobiology, 2019, 29(5), 397-408.

D. Lee, A. Jayaraman, J. S. Kwon, “Identification of a time-varying intracellular signaling model through data clustering and parameter selection: application to NF𝜅B signaling pathway induced by LPS in the presence of BFA,” IET Systems Biology, 2019, 13(4), 169-179.

D. Lee, A. Mohr, J.S. Kwon, H.-J. Wu, "Kinetic Monte Carlo modeling of multivalent binding of CTB proteins with GM1 receptors," Computers & Chemical Engineering, 2018, 118, 283-295.