This Center of Excellence (COE) conducts fundamental research that transforms the way conventional distributed sensing, state estimation, morphing structures, and control are applied to high speed aerospace systems. Our team addresses the limitation of conventional feedback loops using novel sensing motifs and inherent coupling to adaptive structures to create an agile and robust aerospace system with integrated sense, assess and respond functionality. Our inter-disciplinary approach leverages diverse methodologies and team member expertise in information theory, physics-based models, reservoir computing, sensors for high speed environments, morphing structures, control and experimental aerodynamics to meet the goals of an integrated sense, assess and respond framework.