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Christina Holmes, Ph.D.

Christina Holmes
Assistant Professor
Chemical & Biomedical Engineering
Room Number
  • Postdoctoral Fellowship, Department of Neurosurgery, Johns Hopkins University School of Medicine 
  • PhD, Biomedical Engineering, McGill University, 2013
  • MASc, Biomedical Engineering, University of Toronto, 2006
  • BASc, Engineering Science, University of Toronto, 2003
Research Interests
  • Biomaterials
  • Tissue Engineering
  • Regenerative Medicine
  • Nanocarriers for Drug and Gene Delivery

Selected Publications:

  1. Lina, I. A., Ishida, W., Liauw, J. A., Lo, Sheng-fu L., Elder, B. D., Perdomo-Pantoja, A., Theodros, D., Witham, T. F., & Holmes, C. (2018). A mouse model for the study of transplanted bone marrow mesenchymal stem cell survival and proliferation in lumbar spinal fusion. European Spine Journal, 28(4), 710-718. 
  2. Holmes, C. A., Ishida, W., Elder, B. D., Lo, Sheng-Fu Larry, Chen, Y. A., Kim, E., Locke, J., Taylor, M., & Witham, T. F. (2018). The Effects of High-Dose Parathyroid Hormone Treatment on Fusion Outcomes in a Rabbit Model of Posterolateral Lumbar Spinal Fusion Alone and in Combination with Bone Morphogenetic Protein 2 Treatment. World neurosurgery, e366-e374. 
  3. Nyberg, E., Holmes, C., Witham, T., & Grayson, W. L. (2016). Growth factor-eluting technologies for bone tissue engineering. Drug Delivery and Translational Research, 6(2), 184-194.
  4. Elder, B. D., Holmes, C., Goodwin, C. R., Lo, S.-F., Puvanesarajah, V., Kosztowski, T. A., Locke, J. E., & Witham, T. F. (2015). A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion. Annals of Biomedical Engineering, 43(5), 1057-1070.
  5. Holmes, C., Tabrizian, M., & Bagnaninchi, P. O. (2015). Motility imaging via optical coherence phase microscopy enables label-free monitoring of tissue growth and viability in 3D tissue-engineering scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 641-645.
  6. Holmes, C., Daoud, J., Bagnaninchi, P. O., & Tabrizian, M. (2014). Polyelectrolyte Multilayer Coating of 3D Scaffolds Enhances Tissue Growth and Gene Delivery: Non‐Invasive and Label‐Free Assessment. Advanced Healthcare Materials, 3(4), 572-580.
  7. Holmes, C. A., Tabrizian, M. (2013). Substrate-mediated gene delivery from glycol-chitosan/hyaluronic acid polyelectrolyte multilayer films. ACS Applied Materials & Interfaces5(3), 524-531.
  8. Holmes, C. A., Tabrizian, M. (2012). Enhanced MC3T3 preosteoblast viability and adhesion on polyelectrolyte multilayer films composed of glycol‐modified chitosan and hyaluronic acid. Journal of Biomedical Materials Research Part A100(2), 518-526.
  9. Holmes, C., Stanford, W. L. (2007). Concise review: Stem cell antigen-1: Expression, function, and enigma. Stem Cells25(6), 1339-1347.
  10. Holmes, C., Khan, T. S., Owen, C., Ciliberti, N., Grynpas, M. D., & Stanford, W. L. (2007). Longitudinal Analysis of Mesenchymal Progenitors and Bone Quality in the Stem Cell Antigen‐1–Null Osteoporotic Mouse. Journal of Bone and Mineral Research22(9), 1373-1386.

Book Chapters

  1. Holmes C., Tabrizian M. “Surface Functionalization of Biomaterials” in Stem Cell Biology and Tissue Engineering in Dental Science, Elsevier/Academic Press. 2015